Glutathione Reduced is an ubiquitous antioxidant involved in many cellular functions such as detoxification, amino acid transport, production of coenzymes and recycling of vitamins E and C. By serving as a critical nucleophilic scavenger, glutathione blocks free radical damage to all types of tissues.
Nowadays fair skin is in fashion, and glutathione skin whitening has become one of the popular options to lighten complexion.
Anecdotal evidence suggests that glutathione supplements make skin lighter, and even erase sun spots, freckles and age spots.
ORAL GLUTATHIONE SKIN WHITENING
There are many forums online where personal experiences are being shared, and discussions are underway about how fast the effect can be achieved with oral glutathione and what the best dosages are.
Anecdotal results vary from person to person – glutathione skin whitening effect can be achieved anywhere between 1 month to 1 year of daily oral supplementation, suggested dosages are 500-1,000 mg/day. Oral glutathione is usually well tolerated because it is a small protein molecule most of which gets broken down during digestion.
“Glutathione as an oral whitening agent: a randomized, double-blind, placebo-controlled study”, April 2012; 23(2):97-102, Journal of Dermatological Treatment.
Arjinpathana N, Asawanonda P.
Division of Dermatology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
This study is the first one to confirm the effect of oral glutathione skin whitening in general population.
In this study 60 healthy medical students from Bangkok were randomized to receive either glutathione capsules, 500 mg/day in two divided doses, or placebo for 4 weeks. The outcome of mean reduction of melanin indices was measured at six different sites on the body.
At 4 weeks, the melanin indices decreased consistently at all six sites in subjects who received glutathione. But the reductions were statistically significantly greater than in those receiving placebo only at two sites out of six: the right side of the face and the sun-exposed left forearm. There were no reported side effects from using oral glutathione in these prescribed dosages.
Some people go to the extremes of considering expensive glutathione injections or glutathione IV (intravenous administration) to whiten their skin because these methods provide faster results of delivering glutathione into the bloodstream than oral glutathione.
However, it is not advisable to use glutathione injections or IV to lighten the skin color. Administration of injections or IV requires skill and dosages are not clearly defined. One of the side effects may be whitening of hair because hair color is dependent on the amounts of melanin which appears to be decreased by oral or injectable glutathione. Not to mention possible infections, allergic reactions such as rashes, hives and skin swelling. Hence why Oral Glutathione is preferred